pI: 7.6184 |
Length (AA): 512 |
MW (Da): 56911 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
3 | 510 | 4wju (A) | 34 | 513 | 37.00 | 0 | 1 | 1.29199 | 0.32 |
4 | 512 | 4wjs (A) | 39 | 517 | 35.00 | 0 | 1 | 1.27344 | -0.1 |
340 | 510 | 4xyh (A) | 239 | 350 | 45.00 | 0.0000031 | 0.95 | 0.156284 | 1.22 |
394 | 471 | 3zwl (D) | 5 | 82 | 22.00 | 0.0014 | 0.38 | 0.497644 | -0.98 |
456 | 511 | 3bg1 (A) | 28 | 87 | 38.00 | 0.004 | 0.6 | 0.509675 | -0.41 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127223)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G52820 | Notchless protein homolog |
Babesia bovis | BBOV_II003080 | WD-repeat protein, putative |
Brugia malayi | Bm1_16265 | WD-repeat protein HUSSY-07 |
Candida albicans | CaO19.11260 | three WD-40 domains |
Candida albicans | CaO19.11259 | five WD-40 domains |
Candida albicans | CaO19.3778 | five WD-40 domains |
Candida albicans | CaO19.3779 | three WD-40 domains |
Caenorhabditis elegans | CELE_W07E6.2 | Protein W07E6.2 |
Cryptosporidium hominis | Chro.20040 | notchless |
Cryptosporidium parvum | cgd2_330 | notchless |
Dictyostelium discoideum | DDB_G0295761 | NLE domain-containing protein |
Drosophila melanogaster | Dmel_CG2863 | Notchless |
Echinococcus granulosus | EgrG_001015100 | notchless 1 |
Entamoeba histolytica | EHI_130870 | WD domain containing protein |
Echinococcus multilocularis | EmuJ_001015100 | notchless 1 |
Giardia lamblia | GL50803_13667 | Notchless |
Homo sapiens | ENSG00000073536 | notchless homolog 1 (Drosophila) |
Leishmania braziliensis | LbrM.24.2340 | notchless homolog, putative |
Leishmania donovani | LdBPK_242350.1 | notchless homolog, putative |
Leishmania infantum | LinJ.24.2350 | notchless homolog, putative |
Leishmania major | LmjF.24.2260 | notchless homolog, putative |
Leishmania mexicana | LmxM.24.2260 | notchless homolog, putative |
Loa Loa (eye worm) | LOAG_02482 | WD-repeat protein HUSSY-07 |
Mus musculus | ENSMUSG00000020692 | notchless homolog 1 (Drosophila) |
Neospora caninum | NCLIV_052610 | hypothetical protein, conserved |
Oryza sativa | 4347950 | Os10g0104500 |
Oryza sativa | 4350837 | Os11g0594200 |
Onchocerca volvulus | OVOC13494 |
|
Plasmodium berghei | PBANKA_0903000 | ribosome assembly protein 4, putative |
Plasmodium falciparum | PF3D7_1146000 | ribosome assembly protein 4, putative |
Plasmodium knowlesi | PKNH_0943900 | ribosome assembly protein 4, putative |
Plasmodium vivax | PVX_092900 | WD domain, G-beta repeat domain containing protein |
Plasmodium yoelii | PY02598 | notchless-related |
Saccharomyces cerevisiae | YCR072C | Rsa4p |
Schistosoma japonicum | Sjp_0013780 | Notchless protein homolog 1, putative |
Schistosoma mansoni | Smp_000600 | notchless homolog 1 |
Schmidtea mediterranea | mk4.019277.01 | Protein Notchless |
Schmidtea mediterranea | mk4.004217.02 | Notchless-1 |
Trypanosoma brucei gambiense | Tbg972.8.5990 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.8.5990 | NLE (NUC135) domain/WD domain, G-beta repeat, putative |
Trypanosoma congolense | TcIL3000_8_5760 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.511897.28 | NLE (NUC135) domain/WD domain, G-beta repeat, putative |
Trypanosoma cruzi | TcCLB.511075.20 | notchless homolog, putative |
Toxoplasma gondii | TGME49_215740 | notchless, putative |
Theileria parva | TP04_0285 | hypothetical protein |
Trichomonas vaginalis | TVAG_356470 | WD repeat domain, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.5990 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.5990 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.5990 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.8.5990 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_W07E6.2 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_W07E6.2 | Caenorhabditis elegans | slow growth | wormbase |
CELE_W07E6.2 | Caenorhabditis elegans | sterile | wormbase |
YCR072C | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_215740 | Toxoplasma gondii | Probably essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.